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Trees within the order Fagales possess particularly potent allergens, e.g. the prototypical Bet v 1, the major white birch (Betula 3️⃣ verrucosa - now called B. pendula) pollen antigen. Bet v 1 is the main cause of type I allergies observed 3️⃣ in early spring. Type I, or immunoglobulin E-mediated (IgE-mediated) allergies affect 1 in 5 people in Europe and North America. 3️⃣ Commonly observed symptoms are hay fever, dermatitis, asthma and, in severe cases, anaphylactic shock. First contact with these allergens results 3️⃣ in sensitisation; subsequent contact produces a cross-linking reaction of IgE on mast cells and concomitant release of histamine. The inevitable 3️⃣ symptoms of an allergic reaction ensue.
Categorization [ edit ]
A nomenclature system has been established for antigens (allergens) that cause IgE-mediated 3️⃣ atopic allergies in humans.[2] This nomenclature system is defined by a designation that is composed of the first three letters 3️⃣ of the genus; a space; the first letter of the species name; a space and an Arabic number. In the 3️⃣ event that two species names have identical designations, they are discriminated from one another by adding one or more letters 3️⃣ (as necessary) to each species designation.
The allergens in this family include allergens with the following designations: Bet v 1, Dau 3️⃣ c 1, and Pru a 1. Other proteins belonging to this family include the major pollen allergens:
Structure [ edit ]